Cartoon Info

References for channel structures:

Sachyani 2014

Xu 2012

Howard 2007

The cartoon on each variant page shows the membrane folding pattern and some other structural features of a KCNQ2/3 subunit. A small circle represents each of the 872 amino acids. Dark blue circles are placed at borders between important functional domains. Above, the functional domains are labelled in red: intracellular N and C terminals, the six transmembrane segments (S1 through S6), linkers between the transmembrane segments, and C terminal segments known to be helical structures (A to D).

 

Each channel is made up of 4 subunits, arranged around the central ion pathway (or pore). The cartoon below shows a assembled channel with one subunit removed to reveal the central potassium (K) ion pathway.

Last Updated: 12/02/2015

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